"怎么"inEnglishcanbereadas"how"or"what"dependingonthecontext."怎么了"canbereadas"whathappened"or"what'swrong"inEnglish."怎么读"canbereadas"howtoread"inEnglish.
"怎么" in English can be read as "how" or "what" depending on the context.
"怎么了" can be read as "what happened" or "what's wrong" in English.
"怎么读" can be read as "how to read" in English.